Публикации лаборатории трансляционной медицины и биоинформатики

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2021

  • М. Байкенова , В. А. Черешнев, К. В. Соколова, И. Ф. Гетте, В. В. Емельянов, И. Г. Данилова. Инсулин+-клетки и основные транскрипционные факторы (Pdx1, MafA и Ngn3) в печени животных при экспериментальном моделировании сахарного диабета 1-го и 2-го типа. // Журнал эволюционной биохимии и физиологии. - 2021. -Т.57. - №4. - Р. 300-309
  • M. B. Baykenova, V. A. Chereshnev, K. V. Sokolova, I. F. Gette, V. V. Emelianov, I. G. Danilova. Insulin-positive cells in liver and exocrine part of pancreas in animals with experimental diabetes mellitus. Bulletin of Siberian Medicine. 2021. V. 19 (4), pp. 6-13 (Scopus, WoS).
  • Kuzmin V.S., Ivanova, A. D., Potekhina V. M., Samoilova D. V., Ushenin K. S., Shvetsova A. A., Petrov A. M. The susceptibility of the rat pulmonary and caval vein myocardium to the catecholamine‐induced ectopy changes oppositely in postnatal development. // The Journal of Physiology. – 2021. – V. 599, № 11. – P. 2803 - 2821.
  • Gerzen, O.P., Nabiev, S.R. & Nikitina, L.V. Influence of Chronic Lead Intoxication on Functional Characteristics and Isoform Composition of Left Ventricular Myosin in the Rat Heart. J Evol Biochem Phys 57, 896–903 (2021).
  • Nesterova T., Ushenin K., Shmarko D., Solovyova O. Electrophysiological Biomarkers for Age-Related Changes in Human Atrial Cardiomyocytes: In Silico Study // ITM Web of Conferences. 2020. 31, 01004.
  • Dokuchaev A., Khamzin S., Solovyova O. In-silico study of age-related ionic remodeling in human ventricular cardiomyocytes // BIO Web Conf. 2020., 22. 01024.
  • Nesterova T., Shmarko D., Ushenin K., Solovyova O. In-silico analysis of aging mechanisms of action potential remodeling in human atrial cardiomyocites // BIO Web of Conferences. 2020. 01025.
  • Volzhaninov and A. Khokhlova. Biomechanical tests for studying contractility and viscoelastic Properties of single cardiac muscle cells // AIP Conference Proceedings 2313, 080033 (2020).
  • A. Khokhlova, T. Myachina, X. Butova, Volzhaninov D., Berg V., Kochurova A., Kuznetsov D, Mukhlynina E., Kopylova G., Shchepkin D. Differing effects of estrogen deficiency on the contractile function of atrial and ventricular myocardium. Biochemical and Biophysical Research Communications, 2021. V. 541, pp. 30-35 (Q2, IF = 2.985)
  • X.A.Butova, T.A.Myachina, A.D.Khokhlova A combined Langendorff-injection technique for simultaneous isolation of single cardiomyocytes from atria and ventricles of the rat heart. MethodsX, 2021.V. 8, 101189. (Scopus Q2, WoS Q4)
  • Lookin O, Butova X, Protsenko Y. The role of pacing rate in modulatory effect of beat-to-beat deformation on immediate and delayed changes in force and Ca-transient of cardiac muscle. Progress in Biophysics and Molecular Biology. 2021, V. 159.pp. 34-45. (Q3, IF = 2.175)
  • Politova, T. Myachina, X. Butova, V. Berg, D. Shchepkin, G. Kopylova and A. Khokhlova. Methods for Studying Myocardial Function at the Cellular and Molecular Levels in Norm and Pathology // AIP Conference Proceedings 2313, 080033 (2020).
  • Klinova S.V., Katsnelson B.A., Minigalieva I.A., Gerzen O.P., Balakin A.A., Lisin R.V., Butova K.A., Nabiev S.R., Lookin O.N., Katsnelson L.B., Privalova L.I., Kuznetsov D.A., Shur V.Y., Shishkina E.V., Makeev O.H., Valamina I.E., Panov V.G., Sutunkova M.P., NikitinaL.V., Protsenko Y. L. Cardioinotropic Effects in Subchronic Intoxication of Rats with Lead and/or Cadmium Oxide Nanoparticles. // International Journal of Molecular Sciences. – 2021. – V. 22. – №. 7. – P. 3466.  

2022

  • Байкенова М. Б., Соколова К.В., Гетте И.Ф., Данилова И.Г. Роль лейкоцитов в повреждении печени при моделировании сахарного диабета 1 и 2 типа // Медицинская иммунология. – 2022. – Т. 24, №. 2. – С. 263–272.
  • Dordiuk V., Demicheva E., Espino F. P., Ushenin K. Natural language processing for clusterization of genes according to their functions // 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB). – IEEE, 2022. – P. 1–4.
  • Ushenin K., Markov N., Demicheva E., Dordiuk V. Opportunities in Processing of Transmembrane Potential Data with Convolutional Neural Networks // 2022 Ural-Siberian Conference on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT). – IEEE, 2022. – P. 028-031.
  • Markov N., Kotov I., Ushenin K., Bozhko Y. Statistical model for describing heart rate variability in normal rhythm and atrial fibrillation // 2022 Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB). – IEEE, 2022. – P. 130-133.
  • Parikh J., Rumbell T., Butova X., Myachina T., Acero J. C., Khamzin S., Solovyova O., Kozloski J., Khokhlova A., Gurev V. Generative adversarial networks for construction of virtual populations of mechanistic models: simulations to study Omecamtiv Mecarbil action // Journal of pharmacokinetics and pharmacodynamics. – 2022. – V. 49, №. 1. – P. 51–64.
  • Khokhlova A., Myachina T., Volzhaninov D., Butova X., Kochurova A., Berg V., Gette I., Moroz G., Klinova S., Minigalieva I., Solovyova O., Danilova I., Sokolova K., Kopylova G., Shchepkin D. Type 1 Diabetes Impairs Cardiomyocyte Contractility in the Left and Right Ventricular Free Walls but Preserves It in the Interventricular Septum // International Journal of Molecular Sciences. – 2022. – V. 23, №. 3. – P. 1719.
  • Lookin O., Khokhlova A., Myachina T., Butova X., Cazorla O., de Tombe P. Contractile state dependent sarcomere length variability in isolated guinea-pig cardiomyocytes // Frontiers in Physiology. – V. 13. – P. 857471.
  • Khokhlova A., Solovyova O., Kohl P., Peyronnet R. Single cardiomyocytes from papillary muscles show lower preload-dependent activation of force compared to cardiomyocytes from the left ventricular free wall // Journal of Molecular and Cellular Cardiology. – 2022. – V. 166. – P. 127–136.
  • Volzhaninov D., Khokhlova A. The implementation of near-isometric contractions of single cardiomyocytes using a digital micromanipulation system // AIP Conference Proceedings. – AIP Publishing LLC, 2022. – V. 2466. – №. 1. – P. 090024.
  • Sakhno K., Volzhaninov D., Balakin A. The development of the thermostat based on the small sized Peltier elements for maintaining the predefined temperature of a biological preparation // AIP Conference Proceedings. – AIP Publishing LLC, 2022. – V. 2466. – №. 1. – P. 090020.
  • Klinova S. V., Minigalieva I. A., Protsenko Y. L., Sutunkova M. P., Gurvich V. B., Ryabova J. V., Valamina I. E., Gerzen O. P., Nabiev S. R., Balakin A. A., Lookin O. N., Lisin R. V., Kuznetsov D. A., Privalova L. I., Panov V. G., Katsnelson L. B., Nikitina L.V., Katsnelson B. A. Changes in the Cardiotoxic Effects of Lead Intoxication in Rats Induced by Muscular Exercise // International Journal of Molecular Sciences. – 2022. – V. 23. – №. 8. – P. 4417.
  • Khokhlova A., Myachina T., Butova X., Kochurova A., Polyakova E., Galagudza M., Solovyova O., Kopylova G., Shchepkin D. The Acute Effects of Leptin on the Contractility of Isolated Rat Atrial and Ventricular Cardiomyocytes // International journal of molecular sciences. – 2022. – V. 23, №. 15. – P. 8356.
  • Demicheva E. I., Shinwari K., Ushenin K. S., Bolkov M. A. Additional Pathogenic Pathways in RBCK1 Deficiency // Mathematical Biology. – 2022. – V. 17. – №. 2. – P. 174-187.
  • Butova X., Myachina T., Simonova R., Kochurova A., Bozhko Y., Arkhipov M., Solovyova O., Kopylova G., Shchepkin D., Khokhlova A. Peculiarities of the Acetylcholine Action on the Contractile Function of Cardiomyocytes from the Left and Right Atria in Rats // Cells. – 2022. – V. 11, №. 23. – pp. 3809.
  • Kopylova G. V., Berg V. Y., Kochurova A. M., Matyushenko A. M., Bershitsky S. Y, Shchepkin D. V. The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ // Biochemical and Biophysical Research Communications. – 2022. – 588. – P. 29–33.
  • Nefedova V.V., Kopylova G.V., Shchepkin D.V., Kochurova A.M., Kechko O.I., Borzova V.A., Ryabkova N.S., Katrukha I.A., Mitkevich V.A., Bershitsky S.Y., Levitsky D.I., Matyushenko A.M. Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin // International Journal of Molecular Sciences. – 2022. – V. 23. – P. 15723.
  • Gerzen O. P., Nabiev S. R., Klinova S. V., Minigalieva I. A., Sutunkova M. P., Katsnelson B. A., Nikitina L. V. Molecular mechanisms of mechanical function changes of the rat myocardium under subchronic lead exposure // Food and Chemical Toxicology. – 2022. – V. 169. – P.
  • Gerzen O. P., Tyshova V. O., Simanova I. A., Nabiev S. R., Selezneva I. S., Nikitina L. V. The lead-cadmium intoxication: Effects on actin-myosin interaction in the right ventricle myocardium and ways of correction // AIP Conference Proceedings. – AIP Publishing LLC, 2022.– V. 2390. – №. 1. – С. 030021.
  • Klinova, S. V., Protsenko, Y. L., Minigalieva, I. A., Sutunkova, M. P., Gerzen, O. P., Nabiev, S. R., Balakin, A. A., Lisin, R. V., Lookin, O. N., Panov, V. G., Katsnelson, B. A., and Nikitina, L. V. (2022). Cardiotoxicity in rats following subchronic exposure to cadmium chloride solution and cadmium oxide nanoparticles // Public Health and Toxicology, 2(2), 11.

2023

  • Balakin A., Lisin R., Kuznetsov D., Kochurova A., Mukhlynina E., Shchepkin D., Kopylova G., Protsenko Yu. Effects of Omecamtiv Mecarbil on the Tension-Length Loop and Work in Right Ventricular Trabeculae from Rats with Pulmonary Heart Failure // Journal of Evolutionary Biochemistry and Physiology. — 2023. — V. 59(4). — p. 1182-1194.
  • Набиев С.Р., Кочурова А.М., Никитина Л.В., Бельдия Е.А., Матюшенко А.М., Ямпольская Д.С., Бершицкий С.Ю., Копылова Г.В., Щепкин Д.В. N-концевой фрагмент сердечного миозинсвязывающего белка-С увеличивает время актин-миозинового взаимодействия // Бюллетень экспериментальной биологии и медицины. — 2023, — Т. 176(9). — с. 303-306.
  • Mikhryakova P.P., Butova X.A., Myachina T.A., Simonova R.A., Khokhlova A.D. Study of Mechanical Alternans in Single Rat Cardiomyocytes in Acetylcholine-CaCl2 Induced Atrial Fibrillation // Journal of Evolutionary Biochemistry and Physiology. — 2022. — V. 58 (Suppl 1). — p. S13-S21.
  • Gerzen O.P., Votinova V.O., Potoskueva I.K., Tzybina A.E., Nikitina L.V. Direct Effects of Toxic Divalent Cations on Contractile Proteins with Implications for the Heart: Unraveling Mechanisms of Dysfunction // International Journal of Molecular Sciences. ‒ 2023. ‒ V. 24(13). — 10579.
  • Gerzen O.P., Lisin R.V., Balakin A.A., Mukhlynina E.A., Kuznetsov D.A., Nikitina L.V., Protsenko, Y.L. Characteristics of the right atrial and right ventricular contractility in a model of monocrotaline-induced pulmonary arterial hypertension // Journal of Muscle Research and Cell Motility. — 2023. — p. 1-11.
  • Butova X., Myachina T., Simonova R., Kochurova A., Mukhlynina E., Kopylova G., Shchepkin D., Khokhlova A. The inter-chamber differences in the contractile function between left and right atrial cardiomyocytes in atrial fibrillation in rats // Frontiers in Cardiovascular Medicine. ‒ 2023. ‒ V. 10. ‒ 1203093.
  • Ushenin K., Dordiuk V., Dzhigil M. Reconstruction of data inside myocardium from spatial measurements with neural networks // 2023 IEEE Ural-Siberian Conference on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT), Yekaterinburg, Russian Federation. — 2023. — pp. 87-90.
  • Markov N., Ushenin K., Bozhko Y. A Convolutional Recurrent Model for the Identification of Patients with Atrial Fibrillation Based on Heart Rate Variability Data During Sinus Rhythm // 2023 IEEE Ural-Siberian Conference on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT), Yekaterinburg, Russian Federation. — 2023. — pp. 072-075.
  • Dordiuk V., Dzhigil M., Ushenin K. Surface Mesh Segmentation Based on Geometry // 2023 IEEE Ural-Siberian Conference on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT), Yekaterinburg, Russian Federation. — 2023. — pp. 270-273.
  • Dordiuk M., Dzhigil M., Ushenin K. Benefits of mirror weight symmetry for 3D mesh segmentation in biomedical applications // 2023 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB), Novosibirsk, Russian Federation. p. 100-107.
  • Bazhutina A., Ushenin K., Khamzin S., Kabak V., Zubarev S., Lebedev D., Solovyova O. Personalized cardiac computer models and machine-learning for target vein selection in cardiac resynchronisation therapy // 2023 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB), Novosibirsk, Russian Federation. p. 236-241.
  • Dokuchaev A., Zubarev S., Pozdina V., Teregulov Y., Lebedev D. Vectorcardiogram Planarity Index Predicts Response to Cardiac Resynchronisation Therapy // 2023 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB), Novosibirsk, Russian Federation. p. 128-132.
  • Khamzin S., Bazhutina A., Makarov A. Influence of Myocardial Fibrosis on Ventricular Activation in LBBB and during Biventricular Pacing: Simulation Study // 2023 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine (CSGB), Novosibirsk, Russian Federation. p. 227-230.

2024

  • Demicheva Ekaterina, Vladislav Dordiuk, Fernando Polanco Espino, Konstantin Ushenin, Saied Aboushanab, Vadim Shevyrin, Aleksey Buhler, Elena Mukhlynina, Olga Solovyova, Irina Danilova, Elena Kovaleva. Advances in Mass Spectrometry-Based Blood Metabolomics Profiling for Non-Cancer Diseases: A Comprehensive Review // Metabolites (MDPI), — 2024. —V. 14. – № 1 (54)
  • Gerzen O, Potoskueva I, Votinova V, Sergeeva K, Tyganov S, Tzybina A, Shenkman BS, Nikitina L. Mechanical interaction of myosin and native thin filament in the disused rat soleus muscle. Life Sciences in Space Research. 2024 May 1;41:80-5.
  • Gerzen OP, Potoskueva IK, Tzybina AE, Myachina TA, Nikitina LV. Cardiac Myosin and Thin Filament as Targets for Lead and Cadmium Divalent Cations. Biochemistry (Moscow). 2024 Jul;89(7):1273-82.
  • Klinova SV, Minigalieva IA, Sutunkova MP, Valamina IE, Gerzen OP, Nikitina LV, Ryabova YV, Shaikhova DR, Shelomentsev IG, Mustafina IZ, Orlov MS. A novel approach to assessing cardiotoxic effects of nanoparticles in a toxicological experiment. Hygiene and Sanitation. 2024 Dec 15;103(9):1017-24.
  • Butova, X. A., Myachina, T. A., Simonova, R. A., Kochurova, A. M., Kopylova, G. V., Khokhlova, A. D., & Shchepkin, D. V. Contractile Characteristics of Single Cardiomyocytes in the Myocardial Sleeves of the Pulmonary Veins of Guinea Pigs //Journal of Evolutionary Biochemistry and Physiology. – 2024. – Т. 60. – №. 5. – С. 1741-1750.

2025

  • Butova X.А., Khokhlova А.D., Kopylova G.V., Shchepkin D.V., Protsenko Yu.L. Interatrial features of length-dependent regulation of myocardial force in paroxysmal atrial fibrillation in rats // Bulletin of Experimental Biology and Medicine 179(1): 31-36
  • Myachina, T. A., Butova, X. A., Simonova, R. A., Volzhaninov, D. A., Kochurova, A. M., Kopylova, G. V., Shchepkin D.V., Khokhlova, A. D. The Contractile Function of Ventricular Cardiomyocytes Is More Sensitive to Acute 17β-Estradiol Treatment Compared to Atrial Cardiomyocytes //Cells. – 2025. – Т. 14. – №. 8. – С. 561.

Патенты и свидетельства

  1. Привалова Л.И., Клинова С.В., Минигалиева И.А., Сутункова М.П., Валамина И.Е., Макеев О.Г., Проценко Ю.Л., Никитина Л.В., Герцен О.П., Гурвич В.Б., Кацнельсон Б.А. 2020. «Способ повышения устойчивости организма к комбинированному вредному действию свинца и кадмия» (патент №2712954).
  2. Волжанинов Д.А. 2020. «Программа управления цифровыми манипуляторами для задания последовательного растяжения биологической ткани или одиночной клетки» (№2021610500).